{"product_id":"aclasta-5mg-100ml-sol-perf","title":"Aclasta 5mg\/100ml sol.perf.","description":"\u003cp align=\"left\"\u003e\u003cspan style=\"color: #000000;\"\u003e\u003cspan style=\"font-family: Times New Roman, serif;\"\u003e\u003cspan style=\"font-size: medium;\"\u003e\u003cspan style=\"font-size: large;\"\u003e\u003cstrong\u003eAclasta 5 mg soluţie perfuzabilă \u003c\/strong\u003e\u003c\/span\u003e\u003c\/span\u003e\u003c\/span\u003e\u003c\/span\u003e\u003c\/p\u003e\r\n\u003cp align=\"left\"\u003e\u003cspan style=\"color: #000000;\"\u003e\u003cspan style=\"font-family: Times New Roman, serif;\"\u003e\u003cspan style=\"font-size: medium;\"\u003e\u003cspan style=\"font-size: large;\"\u003e Acid zoledronic \u003c\/span\u003e\u003c\/span\u003e\u003c\/span\u003e\u003c\/span\u003e\u003c\/p\u003e\r\n\u003cp align=\"left\"\u003e \u003c\/p\u003e\r\n\u003cp align=\"left\"\u003e\u003cspan style=\"color: #000000;\"\u003e\u003cspan style=\"font-family: Times New Roman, serif;\"\u003e\u003cspan style=\"font-size: medium;\"\u003e\u003cspan style=\"font-size: large;\"\u003e\u003cstrong\u003eCitiţi cu atenţie şi în întregime acest prospect înainte de a începe să utilizaţi acest medicament deoarece conţine informaţii importante pentru dumneavoastră. \u003c\/strong\u003e\u003c\/span\u003e \u003c\/span\u003e\u003c\/span\u003e\u003c\/span\u003e\u003c\/p\u003e\r\n\u003cul\u003e\r\n\u003cli\u003e\r\n\u003cp align=\"left\"\u003e\u003cspan style=\"color: #000000;\"\u003e\u003cspan style=\"font-family: Times New Roman, serif;\"\u003e\u003cspan style=\"font-size: large;\"\u003ePăstraţi acest prospect. S-ar putea să fie necesar să-l recitiţi. \u003c\/span\u003e\u003c\/span\u003e\u003c\/span\u003e\u003c\/p\u003e\r\n\u003c\/li\u003e\r\n\u003cli\u003e\r\n\u003cp align=\"left\"\u003e\u003cspan style=\"color: #000000;\"\u003e\u003cspan style=\"font-family: Times New Roman, serif;\"\u003e\u003cspan style=\"font-size: large;\"\u003eDacă aveţi orice întrebări suplimentare, adresaţi-vă medicului dumneavoastră sau farmacistului. \u003c\/span\u003e\u003c\/span\u003e\u003c\/span\u003e\u003c\/p\u003e\r\n\u003c\/li\u003e\r\n\u003cli\u003e\r\n\u003cp align=\"left\"\u003e\u003cspan style=\"color: #000000;\"\u003e\u003cspan style=\"font-family: Times New Roman, serif;\"\u003e\u003cspan style=\"font-size: large;\"\u003eAcest medicament a fost prescris numai pentru dumneavoastră. Nu trebuie să-l daţi altor persoane. Le poate face rău. \u003c\/span\u003e\u003c\/span\u003e\u003c\/span\u003e\u003c\/p\u003e\r\n\u003c\/li\u003e\r\n\u003cli\u003e\r\n\u003cp align=\"left\"\u003e\u003cspan style=\"color: #000000;\"\u003e\u003cspan style=\"font-family: Times New Roman, serif;\"\u003e\u003cspan style=\"font-size: large;\"\u003eDacă manifestaţi orice reacţii adverse, adresaţi-vă medicului dumneavoastră sau farmacistului. Acestea \u003c\/span\u003e\u003c\/span\u003e\u003c\/span\u003e\u003c\/p\u003e\r\n\u003c\/li\u003e\r\n\u003c\/ul\u003e\r\n\u003cp align=\"left\"\u003e\u003cspan style=\"color: #000000;\"\u003e\u003cspan style=\"font-family: Times New Roman, serif;\"\u003e\u003cspan style=\"font-size: large;\"\u003einclud orice posibile reacţii adverse nemenţionate în acest prospect. Vezi pct. 4. \u003c\/span\u003e\u003c\/span\u003e\u003c\/span\u003e\u003c\/p\u003e\r\n\u003cp align=\"left\"\u003e \u003c\/p\u003e\r\n\u003ch1 class=\"western\" align=\"left\"\u003e\u003cspan style=\"font-family: 'Times New Roman', serif; font-size: large;\"\u003e1. Ce găsiţi în acest prospect \u003c\/span\u003e\u003c\/h1\u003e\r\n\u003col\u003e\r\n\u003cli\u003e\r\n\u003cp align=\"left\"\u003e\u003cspan style=\"color: #000000;\"\u003e\u003cspan style=\"font-family: Times New Roman, serif;\"\u003e\u003cspan style=\"font-size: large;\"\u003eCe este Aclasta şi pentru ce se utilizează \u003c\/span\u003e\u003c\/span\u003e\u003c\/span\u003e\u003c\/p\u003e\r\n\u003c\/li\u003e\r\n\u003cli\u003e\r\n\u003cp align=\"left\"\u003e\u003cspan style=\"color: #000000;\"\u003e\u003cspan style=\"font-family: Times New Roman, serif;\"\u003e\u003cspan style=\"font-size: large;\"\u003eCe trebuie să ştiţi înainte de a vi se administra Aclasta \u003c\/span\u003e\u003c\/span\u003e\u003c\/span\u003e\u003c\/p\u003e\r\n\u003c\/li\u003e\r\n\u003cli\u003e\r\n\u003cp align=\"left\"\u003e\u003cspan style=\"color: #000000;\"\u003e\u003cspan style=\"font-family: Times New Roman, serif;\"\u003e\u003cspan style=\"font-size: large;\"\u003eCum vi se administrează Aclasta \u003c\/span\u003e\u003c\/span\u003e\u003c\/span\u003e\u003c\/p\u003e\r\n\u003c\/li\u003e\r\n\u003cli\u003e\r\n\u003cp align=\"left\"\u003e\u003cspan style=\"color: #000000;\"\u003e\u003cspan style=\"font-family: Times New Roman, serif;\"\u003e\u003cspan style=\"font-size: large;\"\u003eReacţii adverse posibile \u003c\/span\u003e\u003c\/span\u003e\u003c\/span\u003e\u003c\/p\u003e\r\n\u003c\/li\u003e\r\n\u003cli\u003e\r\n\u003cp align=\"left\"\u003e\u003cspan style=\"color: #000000;\"\u003e\u003cspan style=\"font-family: Times New Roman, serif;\"\u003e\u003cspan style=\"font-size: large;\"\u003eCum se păstrează Aclasta \u003c\/span\u003e\u003c\/span\u003e\u003c\/span\u003e\u003c\/p\u003e\r\n\u003c\/li\u003e\r\n\u003cli\u003e\r\n\u003cp align=\"left\"\u003e\u003cspan style=\"color: #000000;\"\u003e\u003cspan style=\"font-family: Times New Roman, serif;\"\u003e\u003cspan style=\"font-size: large;\"\u003eConţinutul ambalajului şi alte informaţii \u003c\/span\u003e\u003c\/span\u003e\u003c\/span\u003e\u003c\/p\u003e\r\n\u003c\/li\u003e\r\n\u003c\/ol\u003e\r\n\u003cp align=\"left\"\u003e \u003c\/p\u003e\r\n\u003ch1 class=\"western\" align=\"left\"\u003e\u003cspan style=\"font-family: Times New Roman, serif;\"\u003e\u003cspan style=\"font-size: large;\"\u003e2. Ce este Aclasta şi pentru ce se utilizează \u003c\/span\u003e\u003c\/span\u003e\u003c\/h1\u003e\r\n\u003cp align=\"left\"\u003e\u003cspan style=\"color: #000000;\"\u003e\u003cspan style=\"font-family: Times New Roman, serif;\"\u003e\u003cspan style=\"font-size: large;\"\u003eAclasta conţine ca substanţă activă acidul zoledronic. Acesta face parte dintr-un grup de medicamente denumite bifosfonaţi şi este utilizat pentru tratarea și prevenția osteoporozei la femeille aflate în postmenopauză, prevenția fracturilor după fracturi de șold la bărbați și femei, tratamentul osteoporozei la bărbaţi, tratamentul și prevenția osteoporozei cauzate de tratamentul cu corticosteroizi utilizaţi pentru tratarea inflamaţiei şi tratamentul bolii Paget osoase. \u003c\/span\u003e\u003c\/span\u003e\u003c\/span\u003e\u003c\/p\u003e\r\n\u003ch1 class=\"western\" align=\"left\"\u003e\u003cspan style=\"font-family: 'Times New Roman', serif; font-size: large;\"\u003e3.Osteoporoza \u003c\/span\u003e\u003c\/h1\u003e\r\n\u003cp align=\"left\"\u003e\u003cspan style=\"color: #000000;\"\u003e\u003cspan style=\"font-family: Times New Roman, serif;\"\u003e\u003cspan style=\"font-size: large;\"\u003eOsteoporoza este o boală care implică subţierea şi slăbirea oaselor şi este frecventă la femeile aflate la menopauză, dar poate apărea şi la bărbaţi. La menopauză, ovarele femeii nu mai produc hormonul feminin estrogen, care ajută la menţinerea sănătăţii oaselor. După menopauză, se produce o pierdere a ţesutului osos, oasele devin mai slabe şi se rup mai uşor. Osteoporoza se poate produce, de asemenea, la bărbaţi şi femei din cauza utilizării pe termen lung a steroizilor care pot afecta rezistenţa oaselor. Numeroşi pacienţi cu osteoporoză nu prezintă simptome, dar, cu toate acestea, sunt expuse riscului de rupere a oaselor, deoarece osteoporoza le-a slăbit oasele. Concentraţiile plasmatice scăzute ale hormonilor sexuali, mai ales estrogeni proveniţi din androgeni, joacă, de asemenea, un rol în pierderea gradată a ţesutului osos observată la bărbaţi. Atât la femei cât şi la bărbaţi, Aclasta întăreşte oasele şi prin urmare reduce probabilitatea de rupere a acestora. Aclasta este, de asemenea, utilizat la pacieţii care şi-au fracturat de curând şoldul ca urmare a unui traumatism minor, cum ar fi o căzătură, şi, de aceea, prezintă risc pentru fracturi ulterioare ale oaselor. \u003c\/span\u003e\u003c\/span\u003e\u003c\/span\u003e\u003c\/p\u003e\r\n\u003ch1 class=\"western\" align=\"left\"\u003e\u003cspan style=\"font-family: Times New Roman, serif;\"\u003e\u003cspan style=\"font-size: large;\"\u003e4.Boala Paget osoasă\u003c\/span\u003e\u003c\/span\u003e\u003c\/h1\u003e\r\n\u003cp align=\"left\"\u003e\u003cspan style=\"color: #000000;\"\u003e\u003cspan style=\"font-family: Times New Roman, serif;\"\u003e\u003cspan style=\"font-size: large;\"\u003eEste normal ca vechiul material osos să fie îndepărtat şi înlocuit de către unul nou. Acest proces se numeşte remodelare. În cazul bolii Paget, remodelarea osoasă este prea rapidă şi noul material osos se formează în mod dezorganizat, ceea ce îl face mai puţin rezistent decât cel normal. Dacă boala nu este tratată, oasele se deformează, se produc dureri şi se pot rupe. Aclasta acţionează prin aducerea la normal a procesului de remodelare, asigurând formarea de material osos normal, astfel refăcând duritatea osului. \u003c\/span\u003e\u003c\/span\u003e\u003c\/span\u003e\u003c\/p\u003e\r\n\u003cp align=\"left\"\u003e \u003c\/p\u003e\r\n\u003ch1 class=\"western\" align=\"left\"\u003e\u003cspan style=\"font-family: 'Times New Roman', serif; font-size: large;\"\u003e5.Ce trebuie să ştiţi înainte de a vi se administra Aclasta \u003c\/span\u003e\u003c\/h1\u003e\r\n\u003cp align=\"left\"\u003e\u003cspan style=\"color: #000000;\"\u003e\u003cspan style=\"font-family: Times New Roman, serif;\"\u003e\u003cspan style=\"font-size: large;\"\u003eUrmaţi cu atenţie toate instrucţiunile pe care vi le dă medicul dumneavoastră, farmacistul sau asistenta \u003c\/span\u003e\u003c\/span\u003e\u003c\/span\u003e\u003c\/p\u003e\r\n\u003cp align=\"left\"\u003e\u003cspan style=\"color: #000000;\"\u003e\u003cspan style=\"font-family: Times New Roman, serif;\"\u003e\u003cspan style=\"font-size: large;\"\u003emedicală înainte de a vi se administra Aclasta. \u003c\/span\u003e\u003c\/span\u003e\u003c\/span\u003e\u003c\/p\u003e\r\n\u003ch1 class=\"western\" align=\"left\"\u003e\u003cspan style=\"font-family: Times New Roman, serif;\"\u003e\u003cspan style=\"font-size: large;\"\u003e6.Nu trebuie să vi se administreze Aclasta\u003c\/span\u003e\u003c\/span\u003e\u003c\/h1\u003e\r\n\u003cul\u003e\r\n\u003cli\u003e\r\n\u003cp align=\"left\"\u003e\u003cspan style=\"color: #000000;\"\u003e\u003cspan style=\"font-family: Times New Roman, serif;\"\u003e\u003cspan style=\"font-size: large;\"\u003edacă sunteţi alergic la acid zoledronic, la alţi bifosfonaţi sau la oricare dintre celelalte componente ale acestui medicament (enumerate la pct. 6). \u003c\/span\u003e\u003c\/span\u003e\u003c\/span\u003e\u003c\/p\u003e\r\n\u003c\/li\u003e\r\n\u003cli\u003e\r\n\u003cp align=\"left\"\u003e\u003cspan style=\"color: #000000;\"\u003e\u003cspan style=\"font-family: Times New Roman, serif;\"\u003e\u003cspan style=\"font-size: large;\"\u003edacă aveţi hipocalcemie (aceasta înseamnă că valoarea calciului din sânge este prea mică). \u003c\/span\u003e\u003c\/span\u003e\u003c\/span\u003e\u003c\/p\u003e\r\n\u003c\/li\u003e\r\n\u003cli\u003e\r\n\u003cp align=\"left\"\u003e\u003cspan style=\"color: #000000;\"\u003e\u003cspan style=\"font-family: Times New Roman, serif;\"\u003e\u003cspan style=\"font-size: large;\"\u003edacă aveţi probleme renale severe. \u003c\/span\u003e\u003c\/span\u003e\u003c\/span\u003e\u003c\/p\u003e\r\n\u003c\/li\u003e\r\n\u003cli\u003e\r\n\u003cp align=\"left\"\u003e\u003cspan style=\"color: #000000;\"\u003e\u003cspan style=\"font-family: Times New Roman, serif;\"\u003e\u003cspan style=\"font-size: large;\"\u003edacă sunteţi gravidă. \u003c\/span\u003e\u003c\/span\u003e\u003c\/span\u003e\u003c\/p\u003e\r\n\u003c\/li\u003e\r\n\u003cli\u003e\r\n\u003cp align=\"left\"\u003e\u003cspan style=\"color: #000000;\"\u003e\u003cspan style=\"font-family: Times New Roman, serif;\"\u003e\u003cspan style=\"font-size: large;\"\u003edacă alăptaţi. \u003c\/span\u003e\u003c\/span\u003e\u003c\/span\u003e\u003c\/p\u003e\r\n\u003c\/li\u003e\r\n\u003c\/ul\u003e\r\n\u003ch1 class=\"western\" align=\"left\"\u003e\u003cspan style=\"font-family: Times New Roman, serif;\"\u003e\u003cspan style=\"font-size: large;\"\u003e7.Atenţionări şi precauţii \u003c\/span\u003e\u003c\/span\u003e\u003c\/h1\u003e\r\n\u003cp align=\"left\"\u003e\u003cspan style=\"color: #000000;\"\u003e\u003cspan style=\"font-family: Times New Roman, serif;\"\u003e\u003cspan style=\"font-size: large;\"\u003eÎnainte de a vi se administra Aclasta, adresaţi-vă medicului dumneavoastră: \u003c\/span\u003e\u003c\/span\u003e\u003c\/span\u003e\u003c\/p\u003e\r\n\u003cul\u003e\r\n\u003cli\u003e\r\n\u003cp align=\"left\"\u003e\u003cspan style=\"color: #000000;\"\u003e\u003cspan style=\"font-family: Times New Roman, serif;\"\u003e\u003cspan style=\"font-size: large;\"\u003edacă urmaţi un tratament cu orice medicament care conţine acid zoledronic, adică are în compoziţie aceeaşi substanţă activă ca şi Aclasta (acidul zoledronic este utilizat la pacienţii adulţi cu anumite tipuri de cancer pentru prevenirea complicaţiilor osoase sau pentru reducerea cantităţii de calciu). \u003c\/span\u003e\u003c\/span\u003e\u003c\/span\u003e\u003c\/p\u003e\r\n\u003c\/li\u003e\r\n\u003cli\u003e\r\n\u003cp align=\"left\"\u003e\u003cspan style=\"color: #000000;\"\u003e\u003cspan style=\"font-family: Times New Roman, serif;\"\u003e\u003cspan style=\"font-size: large;\"\u003edacă sunteți deshidratat (ați pierdut lichide prin transpirație excesivă, vărsături sau diaree). \u003c\/span\u003e\u003c\/span\u003e\u003c\/span\u003e\u003c\/p\u003e\r\n\u003c\/li\u003e\r\n\u003cli\u003e\r\n\u003cp align=\"left\"\u003e\u003cspan style=\"color: #000000;\"\u003e\u003cspan style=\"font-family: Times New Roman, serif;\"\u003e\u003cspan style=\"font-size: large;\"\u003edacă luați medicamente pentru eliminarea apei din organism (diuretice). \u003c\/span\u003e\u003c\/span\u003e\u003c\/span\u003e\u003c\/p\u003e\r\n\u003c\/li\u003e\r\n\u003cli\u003e\r\n\u003cp align=\"left\"\u003e\u003cspan style=\"color: #000000;\"\u003e\u003cspan style=\"font-family: Times New Roman, serif;\"\u003e\u003cspan style=\"font-size: large;\"\u003edacă aveți cantități reduse de calciu în organism (hipocalcemie). \u003c\/span\u003e\u003c\/span\u003e\u003c\/span\u003e\u003c\/p\u003e\r\n\u003c\/li\u003e\r\n\u003cli\u003e\r\n\u003cp align=\"left\"\u003e\u003cspan style=\"color: #000000;\"\u003e\u003cspan style=\"font-family: Times New Roman, serif;\"\u003e\u003cspan style=\"font-size: large;\"\u003edacă aveţi sau aţi avut probleme renale. \u003c\/span\u003e\u003c\/span\u003e\u003c\/span\u003e\u003c\/p\u003e\r\n\u003c\/li\u003e\r\n\u003cli\u003e\r\n\u003cp align=\"left\"\u003e\u003cspan style=\"color: #000000;\"\u003e\u003cspan style=\"font-family: Times New Roman, serif;\"\u003e\u003cspan style=\"font-size: large;\"\u003edacă nu puteţi lua suplimente zilnice de calciu. \u003c\/span\u003e\u003c\/span\u003e\u003c\/span\u003e\u003c\/p\u003e\r\n\u003c\/li\u003e\r\n\u003cli\u003e\r\n\u003cp align=\"left\"\u003e\u003cspan style=\"color: #000000;\"\u003e\u003cspan style=\"font-family: Times New Roman, serif;\"\u003e\u003cspan style=\"font-size: large;\"\u003edacă vi s-au extirpat parţial sau total pe cale chirurgicală glanda tiroidă sau paratiroidă din regiunea gâtului. \u003c\/span\u003e\u003c\/span\u003e\u003c\/span\u003e\u003c\/p\u003e\r\n\u003c\/li\u003e\r\n\u003cli\u003e\r\n\u003cp align=\"left\"\u003e\u003cspan style=\"color: #000000;\"\u003e\u003cspan style=\"font-family: Times New Roman, serif;\"\u003e\u003cspan style=\"font-size: large;\"\u003edacă vi s-au extirpat părţi din intestin. \u003c\/span\u003e\u003c\/span\u003e\u003c\/span\u003e\u003c\/p\u003e\r\n\u003c\/li\u003e\r\n\u003c\/ul\u003e\r\n\u003cp align=\"left\"\u003e \u003c\/p\u003e\r\n\u003cp align=\"left\"\u003e\u003cspan style=\"color: #000000;\"\u003e\u003cspan style=\"font-family: Times New Roman, serif;\"\u003e\u003cspan style=\"font-size: large;\"\u003eDupă punerea pe piaţă a fost raportată o reacţie adversă numită osteonecroză de maxilar (ONM) \u003c\/span\u003e\u003c\/span\u003e\u003c\/span\u003e\u003c\/p\u003e\r\n\u003cp align=\"left\"\u003e\u003cspan style=\"color: #000000;\"\u003e\u003cspan style=\"font-family: Times New Roman, serif;\"\u003e\u003cspan style=\"font-size: large;\"\u003e(deteriorare a oaselor de la nivelul maxilarului şi mandibulei) la pacienţii cărora li s-a administrat Aclasta (acid zoledronic) pentru tratarea osteoporozei. ONM poate apărea şi după oprirea tratamentului. \u003c\/span\u003e\u003c\/span\u003e\u003c\/span\u003e\u003c\/p\u003e\r\n\u003cp align=\"left\"\u003e \u003c\/p\u003e\r\n\u003cp align=\"left\"\u003e\u003cspan style=\"color: #000000;\"\u003e\u003cspan style=\"font-family: Times New Roman, serif;\"\u003e\u003cspan style=\"font-size: large;\"\u003eEste important să încercaţi să preveniţi apariţia ONM, deoarece aceasta este o boală dureroasă, care poate fi dificil de tratat. Pentru a reduce riscul apariţiei osteonecrozei de maxilar, există câteva măsuri de precauţie pe care trebuie să le luaţi. \u003c\/span\u003e\u003c\/span\u003e\u003c\/span\u003e\u003c\/p\u003e\r\n\u003cp align=\"left\"\u003e\u003cspan style=\"color: #000000;\"\u003e\u003cspan style=\"font-family: Times New Roman, serif;\"\u003e\u003cspan style=\"font-size: large;\"\u003eÎnainte de a vi se administra tratamentul cu Aclasta, spuneţi medicului dumneavoastră, farmacistului sau asistentei medicale dacă \u003c\/span\u003e\u003c\/span\u003e\u003c\/span\u003e\u003c\/p\u003e\r\n\u003cul\u003e\r\n\u003cli\u003e\r\n\u003cp align=\"left\"\u003e\u003cspan style=\"color: #000000;\"\u003e\u003cspan style=\"font-family: Times New Roman, serif;\"\u003e\u003cspan style=\"font-size: large;\"\u003eaveţi orice probleme la nivelul gurii sau dinţilor, cum ar fi igienă dentară necorespunzătare, o boală a gingiilor sau aveţi planificată extracţia unui dinte; \u003c\/span\u003e\u003c\/span\u003e\u003c\/span\u003e\u003c\/p\u003e\r\n\u003c\/li\u003e\r\n\u003cli\u003e\r\n\u003cp align=\"left\"\u003e\u003cspan style=\"color: #000000;\"\u003e\u003cspan style=\"font-family: Times New Roman, serif;\"\u003e\u003cspan style=\"font-size: large;\"\u003enu aţi beneficiat de asistenţă stomatologică de rutină sau nu aţi mai efectuat de mult timp o examinare stomatologică; \u003c\/span\u003e\u003c\/span\u003e\u003c\/span\u003e\u003c\/p\u003e\r\n\u003c\/li\u003e\r\n\u003cli\u003e\r\n\u003cp align=\"left\"\u003e\u003cspan style=\"color: #000000;\"\u003e\u003cspan style=\"font-family: Times New Roman, serif;\"\u003e\u003cspan style=\"font-size: large;\"\u003esunteţi fumător (deoarece aceasta ar putea creşte riscul apariţiei problemelor dentare); \u003c\/span\u003e\u003c\/span\u003e\u003c\/span\u003e\u003c\/p\u003e\r\n\u003c\/li\u003e\r\n\u003cli\u003e\r\n\u003cp align=\"left\"\u003e\u003cspan style=\"color: #000000;\"\u003e\u003cspan style=\"font-family: Times New Roman, serif;\"\u003e\u003cspan style=\"font-size: large;\"\u003eaţi fost tratat anterior cu un bifosfonat (utilizat pentru a trata sau preveni bolile osoase); \u003c\/span\u003e\u003c\/span\u003e\u003c\/span\u003e\u003c\/p\u003e\r\n\u003c\/li\u003e\r\n\u003cli\u003e\r\n\u003cp align=\"left\"\u003e\u003cspan style=\"color: #000000;\"\u003e\u003cspan style=\"font-family: Times New Roman, serif;\"\u003e\u003cspan style=\"font-size: large;\"\u003eluaţi medicamente numite corticosteroizi (sunt sunt prednisolon sau dexametazonă); \u003c\/span\u003e\u003c\/span\u003e\u003c\/span\u003e\u003c\/p\u003e\r\n\u003c\/li\u003e\r\n\u003cli\u003e\r\n\u003cp align=\"left\"\u003e\u003cspan style=\"color: #000000;\"\u003e\u003cspan style=\"font-family: Times New Roman, serif;\"\u003e\u003cspan style=\"font-size: large;\"\u003e- aveţi cancer. \u003c\/span\u003e\u003c\/span\u003e\u003c\/span\u003e\u003c\/p\u003e\r\n\u003c\/li\u003e\r\n\u003c\/ul\u003e\r\n\u003cp align=\"left\"\u003e \u003c\/p\u003e\r\n\u003cp align=\"left\"\u003e\u003cspan style=\"color: #000000;\"\u003e\u003cspan style=\"font-family: Times New Roman, serif;\"\u003e\u003cspan style=\"font-size: large;\"\u003eEste posibil ca medicul dumneavoastră să vă ceară să efectuaţi o examinare stomatologică înainte de a începe tratamentul cu Aclasta. \u003c\/span\u003e\u003c\/span\u003e\u003c\/span\u003e\u003c\/p\u003e\r\n\u003cp align=\"left\"\u003e \u003c\/p\u003e\r\n\u003cp align=\"left\"\u003e\u003cspan style=\"color: #000000;\"\u003e\u003cspan style=\"font-family: Times New Roman, serif;\"\u003e\u003cspan style=\"font-size: large;\"\u003eÎn timpul tratamentului cu Aclasta, trebuie să aveţi o bună igienă orală (inclusiv periaj regulat) şi examinări dentare de rutină. Dacă purtaţi proteză, trebuie să vă asiguraţi că aceasta este potrivită. Dacă faceţi un tratament stomatologic sau urmează să vi se efectueze o intervenţie chirurgicală stomatologică (de exemplu, extracţii de dinţi), spuneţi medicului dumneavoastră despre acest tratament stomatologic şi spuneţi medicului dumneavoastră dentist că sunteţi trataţi cu Aclasta. Spuneţi imediat medicului dumneavoastră sau medicului dumneavoastră dentist dacă aveţi orice probleme la nivelul gurii sau dinţilor, cum sunt un dinte care se clatină, durere sau umflare, ulceraţii care nu se vindecă sau secreţii, deoarece acestea pot fi semne ale osteonecrozei de maxilar. \u003c\/span\u003e\u003c\/span\u003e\u003c\/span\u003e\u003c\/p\u003e\r\n\u003cp align=\"left\"\u003e \u003c\/p\u003e\r\n\u003ch1 class=\"western\" align=\"left\"\u003e\u003cspan style=\"font-family: Times New Roman, serif;\"\u003e\u003cspan style=\"font-size: large;\"\u003e8.Fracturi femurale atipice \u003c\/span\u003e\u003c\/span\u003e\u003c\/h1\u003e\r\n\u003cp align=\"left\"\u003e\u003cspan style=\"color: #000000;\"\u003e\u003cspan style=\"font-family: Times New Roman, serif;\"\u003e\u003cspan style=\"font-size: large;\"\u003eÎn timpul tratamentului pot apărea fracuri ale osului femural, uneori după un traumatism minor sau în absența unui traumatism. Sunteți sfătuiţi să raportați orice durere la nivelul coapsei, şoldului sau la nivel inghinal apărută pe parcursul tratamentului. \u003c\/span\u003e\u003c\/span\u003e\u003c\/span\u003e\u003c\/p\u003e\r\n\u003cp align=\"left\"\u003e \u003c\/p\u003e\r\n\u003ch1 class=\"western\" align=\"left\"\u003e\u003cspan style=\"font-family: Times New Roman, serif;\"\u003e\u003cspan style=\"font-size: large;\"\u003e9.Durere musculo-scheletică \u003c\/span\u003e\u003c\/span\u003e\u003c\/h1\u003e\r\n\u003cp align=\"left\"\u003e\u003cspan style=\"color: #000000;\"\u003e\u003cspan style=\"font-family: Times New Roman, serif;\"\u003e\u003cspan style=\"font-size: large;\"\u003eRareori, la pacienţii la care se administrează bifosfonaţi, inclusiv Aclasta, s-au raportat dureri osoase, \u003c\/span\u003e\u003c\/span\u003e\u003c\/span\u003e\u003c\/p\u003e\r\n\u003cp align=\"left\"\u003e\u003cspan style=\"color: #000000;\"\u003e\u003cspan style=\"font-family: Times New Roman, serif;\"\u003e\u003cspan style=\"font-size: large;\"\u003earticulare şi\/sau musculare severe şi, ocazional, care au condus la incapacitate de muncă. \u003c\/span\u003e\u003c\/span\u003e\u003c\/span\u003e\u003c\/p\u003e\r\n\u003ch1 class=\"western\" align=\"left\"\u003e\u003cspan style=\"font-family: Times New Roman, serif;\"\u003e\u003cspan style=\"font-size: large;\"\u003e10.Analize ale sângelui pentru supraveghere \u003c\/span\u003e\u003c\/span\u003e\u003c\/h1\u003e\r\n\u003cp align=\"left\"\u003e\u003cspan style=\"color: #000000;\"\u003e\u003cspan style=\"font-family: Times New Roman, serif;\"\u003e\u003cspan style=\"font-size: large;\"\u003eMedicul dumneavoastră vă va face analize de sânge pentru a verifica cum vă funcţionează rinichii (concentraţiile de creatinină) înaintea fiecărei doze de Aclasta. Este important să beţi cel puţin 2 pahare cu lichide (de exemplu, apă) cu câteva ore înainte de a vi se administra Aclasta, conform recomandărilor profesionistului din domeniul sănătăţii. \u003c\/span\u003e\u003c\/span\u003e\u003c\/span\u003e\u003c\/p\u003e\r\n\u003ch1 class=\"western\" align=\"left\"\u003e\u003cspan style=\"font-family: Times New Roman, serif;\"\u003e\u003cspan style=\"font-size: large;\"\u003e11.Copii şi adolescenţi \u003c\/span\u003e\u003c\/span\u003e\u003c\/h1\u003e\r\n\u003cp align=\"left\"\u003e\u003cspan style=\"color: #000000;\"\u003e\u003cspan style=\"font-family: Times New Roman, serif;\"\u003e\u003cspan style=\"font-size: large;\"\u003eNu se recomandă administrarea Aclasta la persoanele cu vârste mai mici de 18 ani. Nu s-a studiat \u003c\/span\u003e\u003c\/span\u003e\u003c\/span\u003e\u003c\/p\u003e\r\n\u003cp align=\"left\"\u003e\u003cspan style=\"color: #000000;\"\u003e\u003cspan style=\"font-family: Times New Roman, serif;\"\u003e\u003cspan style=\"font-size: large;\"\u003eutilizarea Aclasta la copii şi adolescenţi. \u003c\/span\u003e\u003c\/span\u003e\u003c\/span\u003e\u003c\/p\u003e\r\n\u003ch1 class=\"western\" align=\"left\"\u003e\u003cspan style=\"font-family: Times New Roman, serif;\"\u003e\u003cspan style=\"font-size: large;\"\u003e12.Aclasta împreună cu alte medicamente \u003c\/span\u003e\u003c\/span\u003e\u003c\/h1\u003e\r\n\u003cp align=\"left\"\u003e\u003cspan style=\"color: #000000;\"\u003e\u003cspan style=\"font-family: Times New Roman, serif;\"\u003e\u003cspan style=\"font-size: large;\"\u003eSpuneţi medicului dumneavoastră, farmacistului sau asistentei medicale dacă luaţi, aţi luat recent sau s-\u003c\/span\u003e\u003c\/span\u003e\u003c\/span\u003e\u003c\/p\u003e\r\n\u003cp align=\"left\"\u003e\u003cspan style=\"color: #000000;\"\u003e\u003cspan style=\"font-family: Times New Roman, serif;\"\u003e\u003cspan style=\"font-size: large;\"\u003ear putea să luaţi orice alte medicamente. \u003c\/span\u003e\u003c\/span\u003e\u003c\/span\u003e\u003c\/p\u003e\r\n\u003cp align=\"left\"\u003e \u003c\/p\u003e\r\n\u003cp align=\"left\"\u003e\u003cspan style=\"color: #000000;\"\u003e\u003cspan style=\"font-family: Times New Roman, serif;\"\u003e\u003cspan style=\"font-size: large;\"\u003eEste important ca medicul dumneavoastră să ştie toate medicamentele pe care le luaţi, în special dacă luaţi medicamente cunoscute că sunt periculoase pentru rinichi (de exemplu antibiotice aminoglicozide) sau diuretice (medicamente pentru eliminarea excesului de apă din organism) care pot cauza deshidratare. \u003c\/span\u003e\u003c\/span\u003e\u003c\/span\u003e\u003c\/p\u003e\r\n\u003ch1 class=\"western\" align=\"left\"\u003e\u003cspan style=\"font-family: Times New Roman, serif;\"\u003e\u003cspan style=\"font-size: large;\"\u003e13.Sarcina şi alăptarea \u003c\/span\u003e\u003c\/span\u003e\u003c\/h1\u003e\r\n\u003cp align=\"left\"\u003e\u003cspan style=\"color: #000000;\"\u003e\u003cspan style=\"font-family: Times New Roman, serif;\"\u003e\u003cspan style=\"font-size: large;\"\u003eNu trebuie să vi se administreze Aclasta dacă sunteţi gravidă sau alăptaţi, credeţi că aţi putea fi gravidă \u003c\/span\u003e\u003c\/span\u003e\u003c\/span\u003e\u003c\/p\u003e\r\n\u003cp align=\"left\"\u003e\u003cspan style=\"color: #000000;\"\u003e\u003cspan style=\"font-family: Times New Roman, serif;\"\u003e\u003cspan style=\"font-size: large;\"\u003esau intenţionaţi să rămâneţi gravidă. \u003c\/span\u003e\u003c\/span\u003e\u003c\/span\u003e\u003c\/p\u003e\r\n\u003cp align=\"left\"\u003e \u003c\/p\u003e\r\n\u003cp align=\"left\"\u003e\u003cspan style=\"color: #000000;\"\u003e\u003cspan style=\"font-family: Times New Roman, serif;\"\u003e\u003cspan style=\"font-size: large;\"\u003eAdresaţi-vă medicului dumneavoastră, farmacistului sau asistentei medicale pentru recomandări înainte de a lua acest medicament. \u003c\/span\u003e\u003c\/span\u003e\u003c\/span\u003e\u003c\/p\u003e\r\n\u003ch1 class=\"western\" align=\"left\"\u003e\u003cspan style=\"font-family: Times New Roman, serif;\"\u003e\u003cspan style=\"font-size: large;\"\u003e14.Conducerea vehiculelor şi folosirea utilajelor\u003c\/span\u003e\u003c\/span\u003e\u003c\/h1\u003e\r\n\u003cp align=\"left\"\u003e\u003cspan style=\"color: #000000;\"\u003e\u003cspan style=\"font-family: Times New Roman, serif;\"\u003e\u003cspan style=\"font-size: large;\"\u003eDacă vă simţiţi ameţit în timpul administrării Aclasta, nu conduceţi vehicule şi nu folosiţi utilaje până \u003c\/span\u003e\u003c\/span\u003e\u003c\/span\u003e\u003c\/p\u003e\r\n\u003cp align=\"left\"\u003e\u003cspan style=\"color: #000000;\"\u003e\u003cspan style=\"font-family: Times New Roman, serif;\"\u003e\u003cspan style=\"font-size: large;\"\u003ecând nu vă simţiţi mai bine. \u003c\/span\u003e\u003c\/span\u003e\u003c\/span\u003e\u003c\/p\u003e\r\n\u003ch1 class=\"western\" align=\"left\"\u003e\u003cspan style=\"font-family: Times New Roman, serif;\"\u003e\u003cspan style=\"font-size: large;\"\u003e15.Aclasta conţine sodiu \u003c\/span\u003e\u003c\/span\u003e\u003c\/h1\u003e\r\n\u003cp align=\"left\"\u003e\u003cspan style=\"color: #000000;\"\u003e\u003cspan style=\"font-family: Times New Roman, serif;\"\u003e\u003cspan style=\"font-size: large;\"\u003eAcest medicament conţine sodiu mai puţin de 1 mmol (23 mg) per flacon de 100 ml, adică practic „nu \u003c\/span\u003e\u003c\/span\u003e\u003c\/span\u003e\u003c\/p\u003e\r\n\u003cp align=\"left\"\u003e\u003cspan style=\"color: #000000;\"\u003e\u003cspan style=\"font-family: Times New Roman, serif;\"\u003e\u003cspan style=\"font-size: large;\"\u003econţine sodiu”. \u003c\/span\u003e\u003c\/span\u003e\u003c\/span\u003e\u003c\/p\u003e\r\n\u003cp align=\"left\"\u003e \u003c\/p\u003e\r\n\u003ch1 class=\"western\" align=\"left\"\u003e\u003cspan style=\"font-family: Times New Roman, serif;\"\u003e\u003cspan style=\"font-size: large;\"\u003e16.Cum vi se administrează Aclasta \u003c\/span\u003e\u003c\/span\u003e\u003c\/h1\u003e\r\n\u003cp align=\"left\"\u003e\u003cspan style=\"color: #000000;\"\u003e\u003cspan style=\"font-family: Times New Roman, serif;\"\u003e\u003cspan style=\"font-size: large;\"\u003eUrmaţi cu atenţie toate instrucţiunile pe care vi le dă medicul dumneavoastră sau asistenta medicală. Discutaţi cu medicul dumneavoastră sau cu asistenta medicală dacă nu sunteţi sigur. \u003c\/span\u003e\u003c\/span\u003e\u003c\/span\u003e\u003c\/p\u003e\r\n\u003ch1 class=\"western\" align=\"left\"\u003e\u003cspan style=\"font-family: Times New Roman, serif;\"\u003e\u003cspan style=\"font-size: large;\"\u003e17.Osteoporoza\u003c\/span\u003e\u003c\/span\u003e\u003c\/h1\u003e\r\n\u003cp align=\"left\"\u003e\u003cspan style=\"color: #000000;\"\u003e\u003cspan style=\"font-family: Times New Roman, serif;\"\u003e\u003cspan style=\"font-size: large;\"\u003eDoza uzuală este de 5 mg, administrată o dată pe an de medicul dumneavoastră sau de asistentă ca o \u003c\/span\u003e\u003c\/span\u003e\u003c\/span\u003e\u003c\/p\u003e\r\n\u003cp align=\"left\"\u003e\u003cspan style=\"color: #000000;\"\u003e\u003cspan style=\"font-family: Times New Roman, serif;\"\u003e\u003cspan style=\"font-size: large;\"\u003esingură perfuzie în venă. Perfuzia va dura cel puţin 15 minute. \u003c\/span\u003e\u003c\/span\u003e\u003c\/span\u003e\u003c\/p\u003e\r\n\u003cp align=\"left\"\u003e \u003c\/p\u003e\r\n\u003cp align=\"left\"\u003e\u003cspan style=\"color: #000000;\"\u003e\u003cspan style=\"font-family: Times New Roman, serif;\"\u003e\u003cspan style=\"font-size: large;\"\u003eÎn cazul în care v-aţi fracturat recent şoldul, se recomandă ca Aclasta să fie administrat la două sau mai multe săptămâni de la operaţia care vi s-a efectuat pentru remedierea fracturii de şold. \u003c\/span\u003e\u003c\/span\u003e\u003c\/span\u003e\u003c\/p\u003e\r\n\u003cp align=\"left\"\u003e \u003c\/p\u003e\r\n\u003cp align=\"left\"\u003e\u003cspan style=\"color: #000000;\"\u003e\u003cspan style=\"font-family: Times New Roman, serif;\"\u003e\u003cspan style=\"font-size: large;\"\u003eEste important să luaţi suplimente de calciu şi vitamina D (de exemplu, comprimate) conform \u003c\/span\u003e\u003c\/span\u003e\u003c\/span\u003e\u003c\/p\u003e\r\n\u003cp align=\"left\"\u003e\u003cspan style=\"color: #000000;\"\u003e\u003cspan style=\"font-family: Times New Roman, serif;\"\u003e\u003cspan style=\"font-size: large;\"\u003erecomandărilor medicului dumneavoastră. \u003c\/span\u003e\u003c\/span\u003e\u003c\/span\u003e\u003c\/p\u003e\r\n\u003cp align=\"left\"\u003e \u003c\/p\u003e\r\n\u003cp align=\"left\"\u003e\u003cspan style=\"color: #000000;\"\u003e\u003cspan style=\"font-family: Times New Roman, serif;\"\u003e\u003cspan style=\"font-size: large;\"\u003eÎn cazul osteoporozei, Aclasta acţionează timp de un an. Medicul dumneavoastră vă va spune când să \u003c\/span\u003e\u003c\/span\u003e\u003c\/span\u003e\u003c\/p\u003e\r\n\u003cp align=\"left\"\u003e\u003cspan style=\"color: #000000;\"\u003e\u003cspan style=\"font-family: Times New Roman, serif;\"\u003e\u003cspan style=\"font-size: large;\"\u003ereveniţi pentru administrarea dozei următoare. \u003c\/span\u003e\u003c\/span\u003e\u003c\/span\u003e\u003c\/p\u003e\r\n\u003ch1 class=\"western\" align=\"left\"\u003e\u003cspan style=\"font-family: Times New Roman, serif;\"\u003e\u003cspan style=\"font-size: large;\"\u003e18.Boala Paget \u003c\/span\u003e\u003c\/span\u003e\u003c\/h1\u003e\r\n\u003cp align=\"left\"\u003e\u003cspan style=\"color: #000000;\"\u003e\u003cspan style=\"font-family: Times New Roman, serif;\"\u003e\u003cspan style=\"font-size: large;\"\u003ePentru tratamentul bolii Paget, Aclasta trebuie prescris numai de medici cu experienţă în tratamentul bolii Paget osoase. \u003c\/span\u003e\u003c\/span\u003e\u003c\/span\u003e\u003c\/p\u003e\r\n\u003cp align=\"left\"\u003e \u003c\/p\u003e\r\n\u003cp align=\"left\"\u003e\u003cspan style=\"color: #000000;\"\u003e\u003cspan style=\"font-family: Times New Roman, serif;\"\u003e\u003cspan style=\"font-size: large;\"\u003eDoza uzuală este de 5 mg, administrată de medicul dumneavoastră sau de asistentă ca perfuzie iniţială în venă. Perfuzia va dura cel puţin 15 minute. Este posibil ca efectul Aclasta să dureze mai mult de un an, iar medicul dumneavoastră vă va anunţa când trebuie să reluaţi tratamentul. \u003c\/span\u003e\u003c\/span\u003e\u003c\/span\u003e\u003c\/p\u003e\r\n\u003cp align=\"left\"\u003e \u003c\/p\u003e\r\n\u003cp align=\"left\"\u003e\u003cspan style=\"color: #000000;\"\u003e\u003cspan style=\"font-family: Times New Roman, serif;\"\u003e\u003cspan style=\"font-size: large;\"\u003eEste posibil ca medicul dumneavoastră să vă sfătuiască să luaţi suplimente de calciu şi vitamina D (de exemplu, comprimate) timp de cel puţin zece zile după ce vi se administrează Aclasta. Este important să urmaţi cu atenţie acest sfat pentru ca valoarea calciului din sângele dumneavoastră să nu devină prea mică în perioada ulterioară administrării perfuziei. Medicul dumneavoastră vă va informa care sunt simptomele asociate hipocalcemiei. \u003c\/span\u003e\u003c\/span\u003e\u003c\/span\u003e\u003c\/p\u003e\r\n\u003ch1 class=\"western\" align=\"left\"\u003e\u003cspan style=\"font-family: Times New Roman, serif;\"\u003e\u003cspan style=\"font-size: large;\"\u003e19.Aclasta împreună cu alimente şi băuturi \u003c\/span\u003e\u003c\/span\u003e\u003c\/h1\u003e\r\n\u003cp align=\"left\"\u003e\u003cspan style=\"color: #000000;\"\u003e\u003cspan style=\"font-family: Times New Roman, serif;\"\u003e\u003cspan style=\"font-size: large;\"\u003eAveţi grijă să consumaţi suficiente lichide (cel puţin unul sau două pahare) înainte şi după tratamentul cu Aclasta, conform recomandărilor medicului. Acest lucru va ajuta la prevenirea deshidratării. Puteţi mânca normal în ziua în care vi se administrează Aclasta. Acest lucru este foarte important în cazul pacienţilor care iau diuretice (medicamente pentru eliminarea apei) şi la vârstnici (cu vârsta de 65 ani şi peste). \u003c\/span\u003e\u003c\/span\u003e\u003c\/span\u003e\u003c\/p\u003e\r\n\u003cp align=\"left\"\u003e \u003c\/p\u003e\r\n\u003cp align=\"left\"\u003e\u003cspan style=\"color: #000000;\"\u003e\u003cspan style=\"font-family: Times New Roman, serif;\"\u003e\u003cspan style=\"font-size: medium;\"\u003e\u003cspan style=\"font-size: large;\"\u003e\u003cstrong\u003eDacă nu vi s-a administrat o doză de Aclasta\u003c\/strong\u003e\u003c\/span\u003e \u003c\/span\u003e\u003c\/span\u003e\u003c\/span\u003e\u003c\/p\u003e\r\n\u003cp align=\"left\"\u003e\u003cspan style=\"color: #000000;\"\u003e\u003cspan style=\"font-family: Times New Roman, serif;\"\u003e\u003cspan style=\"font-size: large;\"\u003eContactaţi medicul sau spitalul cât mai curând posibil pentru a stabili o altă programare. \u003c\/span\u003e\u003c\/span\u003e\u003c\/span\u003e\u003c\/p\u003e\r\n\u003ch1 class=\"western\" align=\"left\"\u003e\u003cspan style=\"font-family: Times New Roman, serif;\"\u003e\u003cspan style=\"font-size: large;\"\u003e20.Înainte de a înceta tratamentul cu Aclasta \u003c\/span\u003e\u003c\/span\u003e\u003c\/h1\u003e\r\n\u003cp align=\"left\"\u003e\u003cspan style=\"color: #000000;\"\u003e\u003cspan style=\"font-family: Times New Roman, serif;\"\u003e\u003cspan style=\"font-size: large;\"\u003eDacă vă gândiţi să încetaţi tratamentul cu Aclasta, vă rugăm să mergeţi la următoarea programare şi să discutaţi acest lucru cu medicul dumneavoastră. \u003c\/span\u003e\u003c\/span\u003e\u003c\/span\u003e\u003c\/p\u003e\r\n\u003cp align=\"left\"\u003e\u003cspan style=\"color: #000000;\"\u003e\u003cspan style=\"font-family: Times New Roman, serif;\"\u003e\u003cspan style=\"font-size: large;\"\u003eMedicul vă va sfătui şi va decide cât timp ar trebui să dureze tratamentul dumneavoastră cu Aclasta. \u003c\/span\u003e\u003c\/span\u003e\u003c\/span\u003e\u003c\/p\u003e\r\n\u003cp align=\"left\"\u003e \u003c\/p\u003e\r\n\u003cp align=\"left\"\u003e\u003cspan style=\"color: #000000;\"\u003e\u003cspan style=\"font-family: Times New Roman, serif;\"\u003e\u003cspan style=\"font-size: large;\"\u003eDacă aveţi orice întrebări suplimentare cu privire la acest medicament, adresaţivă medicului \u003c\/span\u003e\u003c\/span\u003e\u003c\/span\u003e\u003c\/p\u003e\r\n\u003cp align=\"left\"\u003e\u003cspan style=\"color: #000000;\"\u003e\u003cspan style=\"font-family: Times New Roman, serif;\"\u003e\u003cspan style=\"font-size: large;\"\u003edumneavoastră, farmacistului sau asistentei medicale. \u003c\/span\u003e\u003c\/span\u003e\u003c\/span\u003e\u003c\/p\u003e\r\n\u003cp align=\"left\"\u003e \u003c\/p\u003e\r\n\u003ch1 class=\"western\" align=\"left\"\u003e\u003cspan style=\"font-family: Times New Roman, serif;\"\u003e\u003cspan style=\"font-size: large;\"\u003e21.Reacţii adverse posibile \u003c\/span\u003e\u003c\/span\u003e\u003c\/h1\u003e\r\n\u003cp align=\"left\"\u003e\u003cspan style=\"color: #000000;\"\u003e\u003cspan style=\"font-family: Times New Roman, serif;\"\u003e\u003cspan style=\"font-size: large;\"\u003eCa toate medicamentele, acest medicament poate provoca reacţii adverse, cu toate că nu apar la toate persoanele. \u003c\/span\u003e\u003c\/span\u003e\u003c\/span\u003e\u003c\/p\u003e\r\n\u003cp align=\"left\"\u003e \u003c\/p\u003e\r\n\u003cp align=\"left\"\u003e\u003cspan style=\"color: #000000;\"\u003e\u003cspan style=\"font-family: Times New Roman, serif;\"\u003e\u003cspan style=\"font-size: large;\"\u003eReacţiile adverse asociate primei perfuzii sunt foarte, dar sunt mai puţin frecvente după perfuziile ulterioare. Majoritatea reacţiilor adverse, cum sunt febra şi frisoanele, durerile musculare sau articulare şi durerea de cap, apar în primele trei zile după administrarea Aclasta. Simptomele sunt, de obicei, uşoare până la moderate şi dispar în decurs de trei zile. Medicul dumneavoastră vă poate recomanda un analgezic uşor, cum sunt ibuprofenul sau paracetamolul, pentru a atenua aceste reacţii adverse. Posibilitatea de manifestare a acestor reacţii adverse scade la administrările următoare de Aclasta. \u003c\/span\u003e\u003c\/span\u003e\u003c\/span\u003e\u003c\/p\u003e\r\n\u003ch1 class=\"western\" align=\"left\"\u003e\u003cspan style=\"font-family: Times New Roman, serif;\"\u003e\u003cspan style=\"font-size: large;\"\u003e22.Unele reacţii adverse pot fi grave \u003c\/span\u003e\u003c\/span\u003e\u003c\/h1\u003e\r\n\u003cp align=\"left\"\u003e\u003cspan style=\"color: #000000;\"\u003e\u003cspan style=\"font-family: Times New Roman, serif;\"\u003e\u003cspan style=\"font-size: medium;\"\u003e\u003cspan style=\"font-size: large;\"\u003e\u003cu\u003eCu frecvenţă necunoscută (frecvenţa nu poate fi estimată din datele disponibile)\u003c\/u\u003e\u003c\/span\u003e \u003c\/span\u003e\u003c\/span\u003e\u003c\/span\u003e\u003c\/p\u003e\r\n\u003cul\u003e\r\n\u003cli\u003e\r\n\u003cp align=\"left\"\u003e\u003cspan style=\"color: #000000;\"\u003e\u003cspan style=\"font-family: Times New Roman, serif;\"\u003e\u003cspan style=\"font-size: large;\"\u003eFibrilaţie atrială; trebuie să spuneţi medicului dumneavoastră dacă prezentaţi bătăi neregulate ale inimii după ce vi s-a administrat Aclasta. \u003c\/span\u003e\u003c\/span\u003e\u003c\/span\u003e\u003c\/p\u003e\r\n\u003c\/li\u003e\r\n\u003c\/ul\u003e\r\n\u003cp align=\"left\"\u003e \u003c\/p\u003e\r\n\u003cul\u003e\r\n\u003cli\u003e\r\n\u003cp align=\"left\"\u003e\u003cspan style=\"color: #000000;\"\u003e\u003cspan style=\"font-family: Times New Roman, serif;\"\u003e\u003cspan style=\"font-size: large;\"\u003eUmflare, înroşire, durere şi mâncărime la nivelul ochilor sau sensibilitate a ochilor la lumină. \u003c\/span\u003e\u003c\/span\u003e\u003c\/span\u003e\u003c\/p\u003e\r\n\u003c\/li\u003e\r\n\u003c\/ul\u003e\r\n\u003cp align=\"left\"\u003e \u003c\/p\u003e\r\n\u003cul\u003e\r\n\u003cli\u003e\r\n\u003cp align=\"left\"\u003e\u003cspan style=\"color: #000000;\"\u003e\u003cspan style=\"font-family: Times New Roman, serif;\"\u003e\u003cspan style=\"font-size: large;\"\u003eDurere la nivelul gurii şi\/sau maxilarului, umflare sau ulceraţii la nivelul gurii sau maxilarului care nu se vindecă, amorţeală sau senzaţie de greutate la nivelul maxilarului sau slăbire a unui dinte; acestea pot fi semne ale afectării osoase de la nivelul maxilarului (osteonecroză). Spuneţi imediat medicul sau dentistului dumneavoastră dacă prezentaţi aceste simptome în timpul tratamentului cu Aclasta sau după oprirea tratamentului. \u003c\/span\u003e\u003c\/span\u003e\u003c\/span\u003e\u003c\/p\u003e\r\n\u003c\/li\u003e\r\n\u003c\/ul\u003e\r\n\u003cp align=\"left\"\u003e \u003c\/p\u003e\r\n\u003cul\u003e\r\n\u003cli\u003e\r\n\u003cp align=\"left\"\u003e\u003cspan style=\"color: #000000;\"\u003e\u003cspan style=\"font-family: Times New Roman, serif;\"\u003e\u003cspan style=\"font-size: large;\"\u003eReacție alergică severă, ce include erupții pe piele, tulburări respiratorii și cardiace, cu scăderea tensiunii arteriale (reacție anafilactică) și pierderea conștienței (șoc anafilactic), umflarea pielii și a țesutului subcutanat, care se răspândește rapid și implică, de obicei, regiunea feței și a gâtului (cu tulburări de respirație și de deglutiție), dar poate afecta și alte regiuni, de exemplu, intestinul (angioedem). \u003c\/span\u003e\u003c\/span\u003e\u003c\/span\u003e\u003c\/p\u003e\r\n\u003c\/li\u003e\r\n\u003cli\u003e\r\n\u003cp align=\"left\"\u003e\u003cspan style=\"color: #000000;\"\u003e\u003cspan style=\"font-family: Times New Roman, serif;\"\u003e\u003cspan style=\"font-size: large;\"\u003ePot apărea tulburări ale rinichilor (de exemplu, volum scăzut de urină). \u003c\/span\u003e\u003c\/span\u003e\u003c\/span\u003e\u003c\/p\u003e\r\n\u003c\/li\u003e\r\n\u003c\/ul\u003e\r\n\u003cp align=\"left\"\u003e \u003c\/p\u003e\r\n\u003cp align=\"left\"\u003e\u003cspan style=\"color: #000000;\"\u003e\u003cspan style=\"font-family: Times New Roman, serif;\"\u003e\u003cspan style=\"font-size: large;\"\u003eMedicul dumneavoastră trebuie să vă facă un test al sângelui pentru a verifica cum vă funcţionează rinichii înainte de fiecare doză de Aclasta. Este important să beţi cel puţin 2 pahare cu lichide (de exemplu, apă) cu câteva ore înainte de a vi se administra Aclasta, conform recomandărilor profesionistului din domeniul sănătăţii. \u003c\/span\u003e\u003c\/span\u003e\u003c\/span\u003e\u003c\/p\u003e\r\n\u003cp align=\"left\"\u003e \u003c\/p\u003e\r\n\u003cp align=\"left\"\u003e\u003cspan style=\"color: #000000;\"\u003e\u003cspan style=\"font-family: Times New Roman, serif;\"\u003e\u003cspan style=\"font-size: large;\"\u003eDacă prezentaţi oricare dintre reacţiile adverse de mai sus, trebuie să contactaţi imediat medicul. \u003c\/span\u003e\u003c\/span\u003e\u003c\/span\u003e\u003c\/p\u003e\r\n\u003cp align=\"left\"\u003e \u003c\/p\u003e\r\n\u003cp align=\"left\"\u003e\u003cspan style=\"color: #000000;\"\u003e\u003cspan style=\"font-family: Times New Roman, serif;\"\u003e\u003cspan style=\"font-size: large;\"\u003eDe asemenea, Aclasta poate cauza alte reacţii adverse. \u003c\/span\u003e\u003c\/span\u003e\u003c\/span\u003e\u003c\/p\u003e\r\n\u003cp align=\"left\"\u003e\u003cspan style=\"color: #000000;\"\u003e\u003cspan style=\"font-family: Times New Roman, serif;\"\u003e\u003cspan style=\"font-size: medium;\"\u003e\u003cspan style=\"font-size: large;\"\u003e\u003cu\u003eReacțiile adverse la Aclasta în studiile clinice:\u003c\/u\u003e\u003c\/span\u003e \u003c\/span\u003e\u003c\/span\u003e\u003c\/span\u003e\u003c\/p\u003e\r\n\u003cp align=\"left\"\u003e \u003c\/p\u003e\r\n\u003cp align=\"left\"\u003e\u003cspan style=\"color: #000000;\"\u003e\u003cspan style=\"font-family: Times New Roman, serif;\"\u003e\u003cspan style=\"font-size: medium;\"\u003e\u003cspan style=\"font-size: large;\"\u003e\u003cu\u003eFoarte frecvente (pot afecta mai mult de 1 din 10 persoane)\u003c\/u\u003e\u003c\/span\u003e\u003cspan style=\"font-size: large;\"\u003e Febră, dureri articulare și musculare, oboseală, durere. \u003c\/span\u003e\u003c\/span\u003e\u003c\/span\u003e\u003c\/span\u003e\u003c\/p\u003e\r\n\u003cp align=\"left\"\u003e \u003c\/p\u003e\r\n\u003cp align=\"left\"\u003e\u003cspan style=\"color: #000000;\"\u003e\u003cspan style=\"font-family: Times New Roman, serif;\"\u003e\u003cspan style=\"font-size: medium;\"\u003e\u003cspan style=\"font-size: large;\"\u003e\u003cu\u003eFrecvente (pot afecta până la 1 din 10 persoane)\u003c\/u\u003e\u003c\/span\u003e \u003c\/span\u003e\u003c\/span\u003e\u003c\/span\u003e\u003c\/p\u003e\r\n\u003cp align=\"left\"\u003e\u003cspan style=\"color: #000000;\"\u003e\u003cspan style=\"font-family: Times New Roman, serif;\"\u003e\u003cspan style=\"font-size: large;\"\u003eDureri de cap, amețeli, greaţă, vărsături, diaree, dureri la nivelul muşchilor, dureri la nivelul oaselor, dureri la nivelul articulaţiilor, dureri la nivelul spatelui, braţelor sau picioarelor, \u003c\/span\u003e\u003c\/span\u003e\u003c\/span\u003e\u003c\/p\u003e\r\n\u003cp align=\"left\"\u003e\u003cspan style=\"color: #000000;\"\u003e\u003cspan style=\"font-family: Times New Roman, serif;\"\u003e\u003cspan style=\"font-size: large;\"\u003esimptome asemănătoare gripei, oboseală, frisoane, slăbiciune, durere, stare generală de rău, somnolență exagerată, senzație de sufocare, dispepsie, inflamația mucoasei esofagului, durere abdominală, transpirație crescută, rigiditate musculo-scheletică (musculară), umflarea articulațiilor, durere în piept musculo-scheletală, rigiditate articulară, scăderea poftei de mâncare, sete, reacție de fază acută acută (creșterea numărului de globule albe în sânge, a vitezei de sedimentare a hematiilor, febră, etc.). \u003c\/span\u003e\u003c\/span\u003e\u003c\/span\u003e\u003c\/p\u003e\r\n\u003cp align=\"left\"\u003e \u003c\/p\u003e\r\n\u003cp align=\"left\"\u003e\u003cspan style=\"color: #000000;\"\u003e\u003cspan style=\"font-family: Times New Roman, serif;\"\u003e\u003cspan style=\"font-size: medium;\"\u003e\u003cspan style=\"font-size: large;\"\u003e\u003cu\u003eMai puţin frecvente (pot afecta până la 1 din 100 persoane)\u003c\/u\u003e\u003c\/span\u003e \u003c\/span\u003e\u003c\/span\u003e\u003c\/span\u003e\u003c\/p\u003e\r\n\u003cp align=\"left\"\u003e\u003cspan style=\"color: #000000;\"\u003e\u003cspan style=\"font-family: Times New Roman, serif;\"\u003e\u003cspan style=\"font-size: medium;\"\u003e\u003cspan style=\"font-size: large;\"\u003eGripă, infecţii ale căilor respiratorii superioare, număr scăzut de globule roşii în sânge, scăderea apetitului alimentar, insomnie, somnolenţă care poate include stare de vigilenţă şi conştientizare redusă (letargie), senzaţie de mâncărime sau amorţeală, tremor, pierdere temporară a conştienţei, înroșirea ochilor, cu senzație de usturime și durere, sensibilitate la lumină (conjunctivită), dureri în ochi, vertij, tensiune arterială crescută, înroșirea feței, tuse, senzație de sufocare, dispepsie, dureri în etajul\u003c\/span\u003e \u003cspan style=\"font-size: large;\"\u003eabdominal superior, dureri abdominale, regurgitarea conținutului acid al stomacului în esofag, constipaţie, uscăciune în gură, inflamația mucoasei esofagului, erupţii trecătoare pe piele, transpiraţie excesivă, mâncărime, înroşirea pielii, dureri la nivelul gâtului, rigiditate a muşchilor, oaselor şi\/sau articulaţiilor, umflarea articulaţiilor, spasme musculare, dureri la nivelul muşchilor și oaselor cutiei toracice, rigiditatea articulațiilor, inflamația articulațiilor, slăbiciune musculară, rezultate anormale ale testelor renale (creșterea creatininei în sânge, apariția de proteine în urină), urinare frecventă anormală, umflarea mâinilor, gleznelor sau picioarelor, senzaţie de sete, reacţie de fază acută (creșterea numărului de globule albe în sânge, a vitezei de sedimentare a hematiilor, febră, etc.), durere în piept de cauză non-cardiacă. \u003c\/span\u003e\u003c\/span\u003e\u003c\/span\u003e\u003c\/span\u003e\u003c\/p\u003e\r\n\u003cp align=\"left\"\u003e \u003c\/p\u003e\r\n\u003cp align=\"left\"\u003e\u003cspan style=\"color: #000000;\"\u003e\u003cspan style=\"font-family: Times New Roman, serif;\"\u003e\u003cspan style=\"font-size: medium;\"\u003e\u003cspan style=\"font-size: large;\"\u003e\u003cu\u003eRare (pot afecta până la 1 din 1000 persoane)\u003c\/u\u003e\u003c\/span\u003e\u003cspan style=\"font-size: large;\"\u003e Inflamația membranelor ochiului. \u003c\/span\u003e\u003c\/span\u003e\u003c\/span\u003e\u003c\/span\u003e\u003c\/p\u003e\r\n\u003cp align=\"left\"\u003e \u003c\/p\u003e\r\n\u003cp align=\"left\"\u003e\u003cspan style=\"color: #000000;\"\u003e\u003cspan style=\"font-family: Times New Roman, serif;\"\u003e\u003cspan style=\"font-size: medium;\"\u003e\u003cspan style=\"font-size: large;\"\u003eReacții adverse raportate mai cel mai frecvent în studiile individuale sunt: \u003c\/span\u003e\u003cspan style=\"font-size: large;\"\u003e\u003cu\u003eFoarte frecvente (pot afecta mai mult de 1 din 10 persoane)\u003c\/u\u003e\u003c\/span\u003e\u003cspan style=\"font-size: large;\"\u003e Febră, dureri articulare și musculare, oboseală, durere. \u003c\/span\u003e\u003c\/span\u003e\u003c\/span\u003e\u003c\/span\u003e\u003c\/p\u003e\r\n\u003cp align=\"left\"\u003e \u003c\/p\u003e\r\n\u003cp align=\"left\"\u003e\u003cspan style=\"color: #000000;\"\u003e\u003cspan style=\"font-family: Times New Roman, serif;\"\u003e\u003cspan style=\"font-size: medium;\"\u003e\u003cspan style=\"font-size: large;\"\u003e\u003cu\u003eFrecvente (pot afecta mai puțin de 1 din 10 persoane)\u003c\/u\u003e\u003c\/span\u003e \u003c\/span\u003e\u003c\/span\u003e\u003c\/span\u003e\u003c\/p\u003e\r\n\u003cp align=\"left\"\u003e\u003cspan style=\"color: #000000;\"\u003e\u003cspan style=\"font-family: Times New Roman, serif;\"\u003e\u003cspan style=\"font-size: large;\"\u003eSomnolenţă care poate include stare de vigilenţă şi conştientizare redusă (letargie), senzație de sufocare, dispepsie, inflamația mucoasei esofagului, durere abdominală, transpirație excesivă, rigiditate musculo-scheletică (musculară), umflarea articulațiilor, durere toracică musculo-scheletală, rigiditate articulară, scăderea poftei de mâncare, sete, reacție de fază acută. \u003c\/span\u003e\u003c\/span\u003e\u003c\/span\u003e\u003c\/p\u003e\r\n\u003cp align=\"left\"\u003e \u003c\/p\u003e\r\n\u003cp align=\"left\"\u003e\u003cspan style=\"color: #000000;\"\u003e\u003cspan style=\"font-family: Times New Roman, serif;\"\u003e\u003cspan style=\"font-size: medium;\"\u003e\u003cspan style=\"font-size: large;\"\u003e\u003cu\u003eMai puțin frecvente (pot afecta mai puțin de 1 din 100 persoane)\u003c\/u\u003e\u003c\/span\u003e\u003cspan style=\"font-size: large;\"\u003e Inflamația membranei vasculare a ochiului (uveită). \u003c\/span\u003e\u003c\/span\u003e\u003c\/span\u003e\u003c\/span\u003e\u003c\/p\u003e\r\n\u003cp align=\"left\"\u003e \u003c\/p\u003e\r\n\u003cp align=\"left\"\u003e\u003cspan style=\"color: #000000;\"\u003e\u003cspan style=\"font-family: Times New Roman, serif;\"\u003e\u003cspan style=\"font-size: medium;\"\u003e\u003cspan style=\"font-size: large;\"\u003e\u003cu\u003eUrmătoarele reacții adverse au apărut mai rar la pacienții tratați cu Aclasta, decât la cei care au\u003c\/u\u003e\u003c\/span\u003e \u003cspan style=\"font-size: large;\"\u003e\u003cu\u003eadministrat placebo:\u003c\/u\u003e\u003c\/span\u003e \u003c\/span\u003e\u003c\/span\u003e\u003c\/span\u003e\u003c\/p\u003e\r\n\u003cp align=\"left\"\u003e\u003cspan style=\"color: #000000;\"\u003e\u003cspan style=\"font-family: Times New Roman, serif;\"\u003e\u003cspan style=\"font-size: large;\"\u003eConștientizarea bătăilor inimii, inflamația mucoasei stomacului, durere de dinți, reacție la locul de perfuzare, proteina C reactivă crescută în sânge, scăderea calciului în sânge, tulburări de gust. \u003c\/span\u003e\u003c\/span\u003e\u003c\/span\u003e\u003c\/p\u003e\r\n\u003cp align=\"left\"\u003e \u003c\/p\u003e\r\n\u003cp align=\"left\"\u003e\u003cspan style=\"color: #000000;\"\u003e\u003cspan style=\"font-family: Times New Roman, serif;\"\u003e\u003cspan style=\"font-size: medium;\"\u003e\u003cspan style=\"font-size: large;\"\u003e\u003cu\u003eUrmătoarele reacții adverse au fost raportate în perioada după punerea pe piață a medicamentului.\u003c\/u\u003e\u003c\/span\u003e \u003c\/span\u003e\u003c\/span\u003e\u003c\/span\u003e\u003c\/p\u003e\r\n\u003cp align=\"left\"\u003e\u003cspan style=\"color: #000000;\"\u003e\u003cspan style=\"font-family: Times New Roman, serif;\"\u003e\u003cspan style=\"font-size: medium;\"\u003e\u003cspan style=\"font-size: large;\"\u003e\u003cu\u003eCu frecvență necunoscută (frecvența nu poate fi estimată reieșind din datele disponibile).\u003c\/u\u003e\u003c\/span\u003e \u003c\/span\u003e\u003c\/span\u003e\u003c\/span\u003e\u003c\/p\u003e\r\n\u003cp align=\"left\"\u003e\u003cspan style=\"color: #000000;\"\u003e\u003cspan style=\"font-family: Times New Roman, serif;\"\u003e\u003cspan style=\"font-size: large;\"\u003eReacții de hipersensibilitate (alergie), spasm bronșic, modificări pe piele cu înroșire și mâncărime (urticarie), deshidratare ca urmare a simptomelor post-doză, cum ar fi febră, vărsături și diaree; tensiune arterială scăzută, scăderea nivelului de fosfați în sânge. \u003c\/span\u003e\u003c\/span\u003e\u003c\/span\u003e\u003c\/p\u003e\r\n\u003ch1 class=\"western\" align=\"left\"\u003e\u003cspan style=\"font-family: Times New Roman, serif;\"\u003e\u003cspan style=\"font-size: large;\"\u003e23.Raportarea reacţiilor adverse \u003c\/span\u003e\u003c\/span\u003e\u003c\/h1\u003e\r\n\u003cp align=\"left\"\u003e\u003cspan style=\"color: #000000;\"\u003e\u003cspan style=\"font-family: Times New Roman, serif;\"\u003e\u003cspan style=\"font-size: medium;\"\u003e\u003cspan style=\"font-size: large;\"\u003eDacă manifestaţi orice reacţii adverse, adresaţi-vă medicului dumneavoastră sau farmacistului. Acestea includ orice posibile reacţii adverse nemenţionate în acest prospect. De asemenea, puteţi raporta reacţiile adverse direct prin intermediul sistemului naţional de raportare, ale cărui detalii sunt publicate pe web-site-ul Agenţiei Medicamentului şi Dispozitivelor Medicale: \u003c\/span\u003e\u003cspan style=\"font-size: large;\"\u003e\u003cu\u003ewww.amdm.gov.md\u003c\/u\u003e\u003c\/span\u003e\u003cspan style=\"font-size: large;\"\u003e sau email:\u003c\/span\u003e\u003cspan style=\"font-size: large;\"\u003e\u003cu\u003efarmacovigilenta@amdm.gov.md\u003c\/u\u003e\u003c\/span\u003e \u003c\/span\u003e\u003c\/span\u003e\u003c\/span\u003e\u003c\/p\u003e\r\n\u003cp align=\"left\"\u003e \u003c\/p\u003e\r\n\u003cp align=\"left\"\u003e\u003cspan style=\"color: #000000;\"\u003e\u003cspan style=\"font-family: Times New Roman, serif;\"\u003e\u003cspan style=\"font-size: large;\"\u003eRaportând reacţiile adverse, puteţi contribui la furnizarea de informaţii suplimentare privind siguranţa acestui medicament. \u003c\/span\u003e\u003c\/span\u003e\u003c\/span\u003e\u003c\/p\u003e\r\n\u003cp align=\"left\"\u003e \u003c\/p\u003e\r\n\u003ch1 class=\"western\" align=\"left\"\u003e\u003cspan style=\"font-family: Times New Roman, serif;\"\u003e\u003cspan style=\"font-size: large;\"\u003e24.Cum se păstrează Aclasta \u003c\/span\u003e\u003c\/span\u003e\u003c\/h1\u003e\r\n\u003cp align=\"left\"\u003e\u003cspan style=\"color: #000000;\"\u003e\u003cspan style=\"font-family: Times New Roman, serif;\"\u003e\u003cspan style=\"font-size: large;\"\u003eMedicul dumneavoastră, farmacistul sau asistenta medicală ştiu cum se păstrează adecvat Aclasta. \u003c\/span\u003e\u003c\/span\u003e\u003c\/span\u003e\u003c\/p\u003e\r\n\u003cp align=\"left\"\u003e \u003c\/p\u003e\r\n\u003cul\u003e\r\n\u003cli\u003e\r\n\u003cp align=\"left\"\u003e\u003cspan style=\"color: #000000;\"\u003e\u003cspan style=\"font-family: Times New Roman, serif;\"\u003e\u003cspan style=\"font-size: large;\"\u003eNu lăsaţi acest medicament la vederea şi îndemâna copiilor. \u003c\/span\u003e\u003c\/span\u003e\u003c\/span\u003e\u003c\/p\u003e\r\n\u003c\/li\u003e\r\n\u003cli\u003e\r\n\u003cp align=\"left\"\u003e\u003cspan style=\"color: #000000;\"\u003e\u003cspan style=\"font-family: Times New Roman, serif;\"\u003e\u003cspan style=\"font-size: large;\"\u003eNu utilizaţi acest medicament după data de expirare înscrisă pe cutie şi flacon după “EXP”. \u003c\/span\u003e\u003c\/span\u003e\u003c\/span\u003e\u003c\/p\u003e\r\n\u003c\/li\u003e\r\n\u003cli\u003e\r\n\u003cp align=\"left\"\u003e\u003cspan style=\"color: #000000;\"\u003e\u003cspan style=\"font-family: Times New Roman, serif;\"\u003e\u003cspan style=\"font-size: large;\"\u003eFlaconul nedeschis nu necesită condiţii speciale de păstrare. \u003c\/span\u003e\u003c\/span\u003e\u003c\/span\u003e\u003c\/p\u003e\r\n\u003c\/li\u003e\r\n\u003cli\u003e\r\n\u003cp align=\"left\"\u003e\u003cspan style=\"color: #000000;\"\u003e\u003cspan style=\"font-family: Times New Roman, serif;\"\u003e\u003cspan style=\"font-size: large;\"\u003eDupă deschiderea flaconului, produsul trebuie utilizat imediat pentru a evita contaminarea microbiană. În cazul în care nu se utilizează imediat, durata şi condiţiile de păstrare înainte de utilizare sunt responsabilitatea utilizatorului şi, în mod normal, nu trebuie să depăşească 24 ore la o temperatură de 2°C – 8°C. Aşteptaţi ca soluţia ţinută la frigider să atingă temperatura camerei înainte de administrare. \u003c\/span\u003e\u003c\/span\u003e\u003c\/span\u003e\u003c\/p\u003e\r\n\u003c\/li\u003e\r\n\u003c\/ul\u003e\r\n\u003cp align=\"left\"\u003e \u003c\/p\u003e\r\n\u003ch1 class=\"western\" align=\"left\"\u003e\n\u003cspan style=\"font-family: Times New Roman, serif;\"\u003e\u003cspan style=\"font-size: large;\"\u003e25.Conţinutul ambalajului şi alte informaţii \u003c\/span\u003e\u003c\/span\u003e \u003cspan style=\"font-family: Times New Roman, serif;\"\u003e\u003cspan style=\"font-size: large;\"\u003eCe conţine Aclasta \u003c\/span\u003e\u003c\/span\u003e\n\u003c\/h1\u003e\r\n\u003cul\u003e\r\n\u003cli\u003e\r\n\u003cp align=\"left\"\u003e\u003cspan style=\"color: #000000;\"\u003e\u003cspan style=\"font-family: Times New Roman, serif;\"\u003e\u003cspan style=\"font-size: large;\"\u003eSubstanţa activă este acidul zoledronic. Fiecare flacon a 100 ml soluţie conţine acid zoledronic 5 mg (sub formă de monohidrat). \u003c\/span\u003e\u003c\/span\u003e\u003c\/span\u003e\u003c\/p\u003e\r\n\u003c\/li\u003e\r\n\u003c\/ul\u003e\r\n\u003cp align=\"left\"\u003e\u003cspan style=\"color: #000000;\"\u003e\u003cspan style=\"font-family: Times New Roman, serif;\"\u003e\u003cspan style=\"font-size: large;\"\u003eUn ml soluţie conţine acid zoledronic 0,05 mg (sub formă de monohidrat). \u003c\/span\u003e\u003c\/span\u003e\u003c\/span\u003e\u003c\/p\u003e\r\n\u003cul\u003e\r\n\u003cli\u003e\r\n\u003cp align=\"left\"\u003e\u003cspan style=\"color: #000000;\"\u003e\u003cspan style=\"font-family: Times New Roman, serif;\"\u003e\u003cspan style=\"font-size: large;\"\u003eCelelalte componente sunt manitol, citrat de sodiu şi apă pentru preparate injectabile. \u003c\/span\u003e\u003c\/span\u003e\u003c\/span\u003e\u003c\/p\u003e\r\n\u003c\/li\u003e\r\n\u003c\/ul\u003e\r\n\u003cp align=\"left\"\u003e \u003c\/p\u003e\r\n\u003cp align=\"left\"\u003e\u003cspan style=\"color: #000000;\"\u003e\u003cspan style=\"font-family: Times New Roman, serif;\"\u003e\u003cspan style=\"font-size: medium;\"\u003e\u003cspan style=\"font-size: large;\"\u003e\u003cstrong\u003eCum arată Aclasta şi conţinutul ambalajului \u003c\/strong\u003e\u003c\/span\u003e\u003cspan style=\"font-size: large;\"\u003e Aclasta este o soluţie incoloră limpede. \u003c\/span\u003e\u003c\/span\u003e\u003c\/span\u003e\u003c\/span\u003e\u003c\/p\u003e\r\n\u003cp align=\"left\"\u003e\u003cspan style=\"color: #000000;\"\u003e\u003cspan style=\"font-family: Times New Roman, serif;\"\u003e\u003cspan style=\"font-size: large;\"\u003eMedicamentul este ambalat în flacoane din plastic a 100 ml soluţie perfuzabilă pentru utilizare \u003c\/span\u003e\u003c\/span\u003e\u003c\/span\u003e\u003c\/p\u003e\r\n\u003cp align=\"left\"\u003e\u003cspan style=\"color: #000000;\"\u003e\u003cspan style=\"font-family: Times New Roman, serif;\"\u003e\u003cspan style=\"font-size: large;\"\u003eimediată. Aclasta este disponibil în ambalaje conţinând un flacon ca ambalaj unitar. \u003c\/span\u003e\u003c\/span\u003e\u003c\/span\u003e\u003c\/p\u003e\r\n\u003cp align=\"left\"\u003e \u003c\/p\u003e\r\n\u003ch1 class=\"western\" align=\"left\"\u003e\n\u003cspan style=\"font-family: Times New Roman, serif;\"\u003e\u003cspan style=\"font-size: large;\"\u003e26.Deţinătorul Certificatului de Înregistrare şi Fabricantul\u003c\/span\u003e\u003c\/span\u003e \u003cspan style=\"font-family: Times New Roman, serif;\"\u003e\u003cspan style=\"font-size: large;\"\u003eDeţinătorul certificatului de înregistrare \u003c\/span\u003e\u003c\/span\u003e\n\u003c\/h1\u003e\r\n\u003cp align=\"left\"\u003e\u003cspan style=\"color: #000000;\"\u003e\u003cspan style=\"font-family: Times New Roman, serif;\"\u003e\u003cspan style=\"font-size: large;\"\u003eNovartis Pharma AG \u003c\/span\u003e\u003c\/span\u003e\u003c\/span\u003e\u003c\/p\u003e\r\n\u003cp align=\"left\"\u003e\u003cspan style=\"color: #000000;\"\u003e\u003cspan style=\"font-family: Times New Roman, serif;\"\u003e\u003cspan style=\"font-size: large;\"\u003eLichtstrasse 35 \u003c\/span\u003e\u003c\/span\u003e\u003c\/span\u003e\u003c\/p\u003e\r\n\u003cp align=\"left\"\u003e\u003cspan style=\"color: #000000;\"\u003e\u003cspan style=\"font-family: Times New Roman, serif;\"\u003e\u003cspan style=\"font-size: large;\"\u003e4056 Basel \u003c\/span\u003e\u003c\/span\u003e\u003c\/span\u003e\u003c\/p\u003e\r\n\u003cp align=\"left\"\u003e\u003cspan style=\"color: #000000;\"\u003e\u003cspan style=\"font-family: Times New Roman, serif;\"\u003e\u003cspan style=\"font-size: large;\"\u003eElveția \u003c\/span\u003e\u003c\/span\u003e\u003c\/span\u003e\u003c\/p\u003e\r\n\u003ch1 class=\"western\" align=\"left\"\u003e\u003cspan style=\"font-family: Times New Roman, serif;\"\u003e\u003cspan style=\"font-size: large;\"\u003e27.Fabricantul \u003c\/span\u003e\u003c\/span\u003e\u003c\/h1\u003e\r\n\u003cp align=\"left\"\u003e\u003cspan style=\"color: #000000;\"\u003e\u003cspan style=\"font-family: Times New Roman, serif;\"\u003e\u003cspan style=\"font-size: large;\"\u003eNovartis Pharma Stein AG, \u003c\/span\u003e\u003c\/span\u003e\u003c\/span\u003e\u003c\/p\u003e\r\n\u003cp align=\"left\"\u003e\u003cspan style=\"color: #000000;\"\u003e\u003cspan style=\"font-family: Times New Roman, serif;\"\u003e\u003cspan style=\"font-size: large;\"\u003eSchaffhauserstrasse \u003c\/span\u003e\u003c\/span\u003e\u003c\/span\u003e\u003c\/p\u003e\r\n\u003cp align=\"left\"\u003e\u003cspan style=\"color: #000000;\"\u003e\u003cspan style=\"font-family: Times New Roman, serif;\"\u003e\u003cspan style=\"font-size: large;\"\u003e4332 Stein Elveţia \u003c\/span\u003e\u003c\/span\u003e\u003c\/span\u003e\u003c\/p\u003e\r\n\u003cp align=\"left\"\u003e\u003cspan style=\"color: #000000;\"\u003e\u003cspan style=\"font-family: Times New Roman, serif;\"\u003e\u003cspan style=\"font-size: large;\"\u003esau \u003c\/span\u003e\u003c\/span\u003e\u003c\/span\u003e\u003c\/p\u003e\r\n\u003cp align=\"left\"\u003e\u003cspan style=\"color: #000000;\"\u003e\u003cspan style=\"font-family: Times New Roman, serif;\"\u003e\u003cspan style=\"font-size: large;\"\u003eFresenius Kabi Austria GmbH \u003c\/span\u003e\u003c\/span\u003e\u003c\/span\u003e\u003c\/p\u003e\r\n\u003cp align=\"left\"\u003e\u003cspan style=\"color: #000000;\"\u003e\u003cspan style=\"font-family: Times New Roman, serif;\"\u003e\u003cspan style=\"font-size: large;\"\u003eHafnerstrasse 36 \u003c\/span\u003e\u003c\/span\u003e\u003c\/span\u003e\u003c\/p\u003e\r\n\u003cp align=\"left\"\u003e\u003cspan style=\"color: #000000;\"\u003e\u003cspan style=\"font-family: Times New Roman, serif;\"\u003e\u003cspan style=\"font-size: large;\"\u003eA-8055 Graz \u003c\/span\u003e\u003c\/span\u003e\u003c\/span\u003e\u003c\/p\u003e\r\n\u003cp align=\"left\"\u003e\u003cspan style=\"color: #000000;\"\u003e\u003cspan style=\"font-family: Times New Roman, serif;\"\u003e\u003cspan style=\"font-size: large;\"\u003eAustria \u003c\/span\u003e\u003c\/span\u003e\u003c\/span\u003e\u003c\/p\u003e\r\n\u003ch1 class=\"western\" align=\"left\"\u003e\u003cspan style=\"font-family: Times New Roman, serif;\"\u003e\u003cspan style=\"font-size: large;\"\u003e28.Acest prospect a fost revizuit în noiembrie 2019\u003c\/span\u003e\u003c\/span\u003e\u003c\/h1\u003e\r\n\u003cp align=\"left\"\u003e \u003c\/p\u003e\r\n\u003cp align=\"left\"\u003e\u003cspan style=\"color: #000000;\"\u003e\u003cspan style=\"font-family: Times New Roman, serif;\"\u003e\u003cspan style=\"font-size: medium;\"\u003e\u003cspan style=\"font-size: large;\"\u003eInformaţii detaliate privind acest medicament sunt disponibile pe site-ul Agenţiei Medicamentului şi Dispozitivelor Medicale (AMDM) \u003c\/span\u003e\u003ca href=\"http:\/\/nomenclator.amdm.gov.md\/\" target=\"_top\"\u003e\u003cspan style=\"font-size: large;\"\u003e\u003cu\u003ehttp:\/\/nomenclator.amdm.gov.md\/\u003c\/u\u003e\u003c\/span\u003e\u003c\/a\u003e \u003c\/span\u003e\u003c\/span\u003e\u003c\/span\u003e\u003c\/p\u003e\r\n\u003cp align=\"left\"\u003e \u003c\/p\u003e\r\n\u003cp align=\"left\"\u003e\u003cspan style=\"color: #000000;\"\u003e\u003cspan style=\"font-family: Times New Roman, serif;\"\u003e\u003cspan style=\"font-size: large;\"\u003eÎn cazul reacțiilor adverse și \/ sau neconformității tehnice, va rugăm să ne informați prin e-mail: \u003ca href=\"mailto:drugsafety.cis@novartis.com\"\u003edrugsafety.cis@novartis.com \u003c\/a\u003e\u003c\/span\u003e\u003c\/span\u003e\u003c\/span\u003e\u003c\/p\u003e\r\n\u003cp align=\"left\"\u003e \u003c\/p\u003e\r\n\u003cp align=\"left\"\u003e\u003cspan style=\"color: #000000;\"\u003e\u003cspan style=\"font-family: Times New Roman, serif;\"\u003e\u003cspan style=\"font-size: medium;\"\u003e\u003cspan style=\"font-size: large;\"\u003e\u003cstrong\u003eINFORMAŢII PENTRU PERSONALUL MEDICAL \u003c\/strong\u003e\u003c\/span\u003e \u003c\/span\u003e\u003c\/span\u003e\u003c\/span\u003e\u003c\/p\u003e\r\n\u003cp align=\"left\"\u003e\u003cspan style=\"color: #000000;\"\u003e\u003cspan style=\"font-family: Times New Roman, serif;\"\u003e\u003cspan style=\"font-size: large;\"\u003eUrmătoarele informaţii sunt destinate profesioniştilor din domeniul sănătăţii (vezi pct. 3): \u003c\/span\u003e\u003c\/span\u003e\u003c\/span\u003e\u003c\/p\u003e\r\n\u003ch1 class=\"western\" align=\"left\"\u003e\u003cspan style=\"font-family: Times New Roman, serif;\"\u003e\u003cspan style=\"font-size: large;\"\u003e29.Cum se prepară şi se administrează Aclasta \u003c\/span\u003e\u003c\/span\u003e\u003c\/h1\u003e\r\n\u003cp align=\"left\"\u003e\u003cspan style=\"color: #000000;\"\u003e\u003cspan style=\"font-family: Times New Roman, serif;\"\u003e\u003cspan style=\"font-size: medium;\"\u003e\u003cspan style=\"font-size: large;\"\u003e-\u003c\/span\u003e \u003cspan style=\"font-size: large;\"\u003eAclasta 5 mg este o soluţie perfuzabilă pentru utilizare imediată. \u003c\/span\u003e\u003c\/span\u003e\u003c\/span\u003e\u003c\/span\u003e\u003c\/p\u003e\r\n\u003cp align=\"left\"\u003e\u003cspan style=\"color: #000000;\"\u003e\u003cspan style=\"font-family: Times New Roman, serif;\"\u003e\u003cspan style=\"font-size: large;\"\u003ePentru o singură administrare. Cantitatea de soluţie neutilizată trebuie aruncată. Soluţia trebuie utilizată numai dacă este limpede, fără particule şi incoloră. Aclasta nu trebuie amestecat sau administrat intravenos cu nici un alt medicament şi trebuie administrată printr-o linie de perfuzie separată prevăzută cu supapă, cu o viteză de perfuzare constantă. Timpul de perfuzare nu trebuie să fie mai scurt de 15 minute. Aclasta nu trebuie să intre în contact cu nicio soluţie care conţine calciu. Dacă se păstrează la frigider, înainte de administrare, se aşteaptă ca soluţia să revină la temperatura camerei. În timpul preparării perfuziei trebuie utilizate tehnici aseptice. Perfuzia trebuie administrată conform practicilor medicale standard. \u003c\/span\u003e\u003c\/span\u003e\u003c\/span\u003e\u003c\/p\u003e\r\n\u003ch1 class=\"western\" align=\"left\"\u003e\u003cspan style=\"font-family: 'Times New Roman', serif; font-size: large;\"\u003e30.Cum se păstrează Aclasta \u003c\/span\u003e\u003c\/h1\u003e\r\n\u003cul\u003e\r\n\u003cli\u003e\r\n\u003cp align=\"left\"\u003e\u003cspan style=\"color: #000000;\"\u003e\u003cspan style=\"font-family: Times New Roman, serif;\"\u003e\u003cspan style=\"font-size: large;\"\u003eNu lăsaţi acest medicament la vederea şi îndemâna copiilor. \u003c\/span\u003e\u003c\/span\u003e\u003c\/span\u003e\u003c\/p\u003e\r\n\u003c\/li\u003e\r\n\u003cli\u003e\r\n\u003cp align=\"left\"\u003e\u003cspan style=\"color: #000000;\"\u003e\u003cspan style=\"font-family: Times New Roman, serif;\"\u003e\u003cspan style=\"font-size: large;\"\u003eNu utilizaţi acest medicament după data de expirare înscrisă pe cutie şi flacon după EXP. \u003c\/span\u003e\u003c\/span\u003e\u003c\/span\u003e\u003c\/p\u003e\r\n\u003c\/li\u003e\r\n\u003cli\u003e\r\n\u003cp align=\"left\"\u003e\u003cspan style=\"color: #000000;\"\u003e\u003cspan style=\"font-family: Times New Roman, serif;\"\u003e\u003cspan style=\"font-size: large;\"\u003eFlaconul nedeschis nu necesită condiţii speciale de păstrare. \u003c\/span\u003e\u003c\/span\u003e\u003c\/span\u003e\u003c\/p\u003e\r\n\u003c\/li\u003e\r\n\u003cli\u003e\r\n\u003cp align=\"left\"\u003e\u003cspan style=\"color: #000000;\"\u003e\u003cspan style=\"font-family: Times New Roman, serif;\"\u003e\u003cspan style=\"font-size: large;\"\u003eDupă deschiderea flaconului, medicamentul trebuie să fie utilizat imediat pentru a evita contaminarea microbiană. Dacă nu este utilizat imediat, timpul şi condiţiile de păstrare înainte de utilizare sunt responsabilitatea utilizatorului şi, în mod normal, nu trebuie să depăşească 24 ore la 2°C - 8°C. Înainte de administrare, se aşteaptă ca soluţia să revină la temperatura camerei. \u003c\/span\u003e\u003c\/span\u003e\u003c\/span\u003e\u003c\/p\u003e\r\n\u003c\/li\u003e\r\n\u003c\/ul\u003e\r\n\u003cp align=\"left\"\u003e \u003c\/p\u003e\r\n\u003cp align=\"left\"\u003e\u003cspan style=\"color: #000000;\"\u003e\u003cspan style=\"font-family: Times New Roman, serif;\"\u003e\u003cspan style=\"font-size: large;\"\u003eInformaţii detaliate privind acest medicament sunt disponibile pe site-ul Agenţiei Medicamentului şi Dispozitivelor Medicale (AMDM) http:\/\/nomenclator.amed.md\/ \u003c\/span\u003e\u003c\/span\u003e\u003c\/span\u003e\u003c\/p\u003e\r\n\u003cp align=\"left\"\u003e \u003c\/p\u003e\r\n\u003cp align=\"left\"\u003e \u003c\/p\u003e","brand":"Novartis Pharma AG","offers":[{"title":"Default Title","offer_id":45598100521100,"sku":"9411","price":3506.75,"currency_code":"MDL","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0377\/7092\/0076\/files\/9411.jpg?v=1767618336","url":"https:\/\/ff.md\/ru\/products\/aclasta-5mg-100ml-sol-perf","provider":"Farmacia Familiei","version":"1.0","type":"link"}